DPPH is a Swiss response to growing concerns about health data privacy. it is a project whose goals are highly aligned with those of GA4GH, dimensioned for the Swiss scale, but with an international vision. With participation from five research groups across the ETH Domain and the Swiss Data Sciences Center, the project will (i) address the main privacy, security, scalability, and ethical challenges of data sharing for enabling effective P4 medicine; (ii) define an optimal balance between usability, scalability and data protection, and (iii) deploy an appropriate set of computing tools.